Updates on phototerapy in full-term and pre-term neonates with non-hemolytic jaundice
DOI:
https://doi.org/10.28998/rpss.e02106014Abstract
Phototherapy is a low-invasive procedure used in the treatment of jaundice, a clinical manifestation resulted by an increase of total serum bilirubin concentration (TsB). It affects the majority of newborns (NB), especially the premature ones. To assembly the major benefits, consequences and updates about phototherapy treatment in non-hemolytic jaundiced full-term or late preterm (with gestational age ≥ 35 weeks) neonates. This is a systematic review that examines the literature with permutations of the following descriptors: jaundice; phototerapy; and newborn; considering Spanish, English and Portuguese languages and only publications ranging from 2015 to early 2020. Moreover, the boolean operator “AND” was used. The consulted databases were: SciELO, Lilacs, PubMED, MedLine, CAPES periodicals and WorldWildScience. Among the 314 articles founded, 36 were adequate for this study’s theme understanding. The phototherapy is a photocatalyst process able to convert bilirubin molecules into luminirubin, using artificial or solar light. This substance will be more easily excreted, in order to avoid neurotoxic damages. It is considered safe and efficient, even considering individual characteristics and risk factors such as age group, genetics and maternal profile. Thus, phototherapy is deservedly the gold standard in neonatal non-hemolytic jaundice treatment, nevertheless, it deserves wariness in the prescription and commencement, due to the possibility of broad-spectrum side effects. It is also necessary adequate management and infrastructure.
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Descritores em Ciências da Saúde: DeCS [Internet]. ed. 2017. São Paulo (SP): BIREME / OPAS / OMS. 2017 [atualizado 2017 Mai; citado 2017 Jun 13]. Disponível em: http://decs.bvsalud.org.
Fernandes JI de S, Reis AT, da Silva CV, da Silvai AP. Motherly challenges when facing neonatal phototherapy treatment: A descriptive study. Online Brazilian J Nurs. 2016;15(2):188–95. Available from: http://www.objnursing.uff.br/index.php/nursing/article/view/5348/html_2
Cai A, Qi S, Su Z, Shen H, Yang Y, Cai W, et al. A Pilot Metabolic Profiling Study of Patients With Neonatal Jaundice and Response to Phototherapy. Clin Transl Sci. 2016;9(4):216–20. Available from: https://dx.doi.org/10.1111%2Fcts.12401
Armando A, Guzmán M, Fernández YG, Maydelin N, Rodríguez L, Matos AA. Recién nacidos pretérminos tardíos, un grupo de riesgo Late preterm newborns, a group at risk. Rev Cubana Pediatr [Internet]. 2016;88(22):144–55. Disponible en: http://scielo.sld.cu
Maimburg RD, Olsen J, Sun Y. Neonatal hyperbilirubinemia and the risk of febrile seizures and childhood epilepsy. Epilepsy Res [Internet]. 2016;124:67–72. Available from: http://dx.doi.org/10.1016/j.eplepsyres.2016.05.004
Ñacari-Vera M. Prevalencia de ictericia neonatal y factores asociados en recién nacidos a término. Rev Médica Panacea. 2019;7(2):63–8. Disponible em: https://revistas.unica.edu.pe/index.php/panacea/article/view/29/29
Quandt BM, Pfister MS, Lübben JF, Spano F, Rossi RM, Bona G-L, et al. POF-yarn weaves: controlling the light out-coupling of wearable phototherapy devices. Biomed Opt Express. 2017;8(10):4316. Avaliable from: https://dx.doi.org/10.1364%2FBOE.8.004316
Slusher TM, Vaucher YE. Management of neonatal jaundice in low- and middle-income countries. Paediatr Int Child Health [Internet]. 2020;40(1):7–10. Available from: https://doi.org/10.1080/20469047.2019.1707397
Faulhaber FRS, Procianoy RS, Silveira RC. Side Effects of Phototherapy on Neonates. Am J Perinatol. 2019;36(3):252–7. Avaliable from: https://doi.org/10.1055/s-0038-1667379
Waite WM, Taylor JA. Phototherapy for the Treatment of Neonatal Jaundice and Breastfeeding Duration and Exclusivity. Breastfeed Med. 2016;11(4):180–5. Available from: https://doi.org/10.1089/bfm.2015.0170
Ebbesen F, Madsen PH, Vandborg PK, Jakobsen LH, Trydal T, Vreman HJ. Bilirubin isomer distribution in jaundiced neonates during phototherapy with LED light centered at 497 nm (turquoise) vs. 459 nm (blue). Pediatr Res. 2016;80(4):511–5. Avaliable from: https://doi.org/10.1038/pr.2016.115
Clarkson DMG, Satodia P, Hadley I. Safety of neonatal phototherapy lamp exposure. J Radiol Prot [Internet]. 2016;36(4):N46–56. Available from: http://dx.doi.org/10.1088/0952-4746/36/4/N46
American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation [published correction appears in Pediatrics. 2004 Oct;114(4):1138]. Pediatrics. 2004;114(1):297-316. doi:10.1542/peds.114.1.297
Alfieri G, Mir Villamayor R, Genes de Lovera LE, Otazo Arévalos EM, Miño Moreno SG, Bordón Dure JPG. Aplicación del bilirrubinómetro no invasivo en recién nacidos. Pediatría (Asunción). 2019;46(3):158–64. Available from: https://doi.org/10.31698/ped.46032019002
Bhargava V, Tawfik D, Niebuhr B, Jain SK. Transcutaneous bilirubin estimation in extremely low birth weight infants receiving phototherapy: A prospective observational study. BMC Pediatr. 2018;18(1):1–5. https://doi.org/10.1186/s12887-018-1207-7
Bhatt DR, Kristensen-Cabrera AI, Lee HC, Weerasinghe S, Stevenson DK, Bhutani VK, et al. Transcutaneous bilirubinometer use and practices surrounding jaundice in 150 California newborn intensive care units. J Perinatol [Internet]. 2018;38(11):1532–5. Available from: http://dx.doi.org/10.1038/s41372-018-0154-3
Lamola AA. A Pharmacologic View of Phototherapy. Clin Perinatol [Internet]. 2016;43(2):259–76. Available from: http://dx.doi.org/10.1016/j.clp.2016.01.004
Dani C, Becciani S, Pratesi S. Changes in total serum bilirubin during phototherapy in late preterm and term infants with non-haemolytic hyperbilirubinemia. Early Hum Dev [Internet]. 2019;131(February):41–4. Available from: https://doi.org/10.1016/j.earlhumdev.2019.02.007
Chang PW, Waite WM. Evaluation of Home Phototherapy for Neonatal Hyperbilirubinemia. J Pediatr [Internet]. 2020;2–7. Available from: https://doi.org/10.1016/j.jpeds.2020.01.004
Borden, A. R. Satrom, K. M. Wratkowski P et al. Variation in the Phototherapy Practices and Irradiance of Devices in a Major Metropolitan Area. Physiol Behav. 2017;176(5):139–48. Available from: https://doi.org/10.1159/000485369
Nascimento, TF. Avila, MAG. Bocchi S. From suffering to resignation: Grounded Theory approach to maternal experience with newborn in phototherapy. Rev Bras Saúde Materna. 2018;18(1):153–61. Available from: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1013071
Mreihil K, Nakstad B, Stensvold HJ, Benth JŠ, Hansen TWR, Scheck O, et al. Uniform national guidelines do not prevent wide variations in the clinical application of phototherapy for neonatal jaundice. Acta Paediatr Int J Paediatr. 2018;107(4):620–7. Available from: https://doi.org/10.1111/apa.14142
Sherbiny HS, Youssef DM, Sherbini AS, El-Behedy R, Sherief LM. High-intensity light-emitting diode vs fluorescent tubes for intensive phototherapy in neonates. Paediatr Int Child Health. 2016;36(2):127–33. Available from: https://doi.org/10.1179/2046905515y.0000000006
Allam A, Ravikiran SR, Baliga BS, Bhat K, Joseph N. Effect of conventional and LED phototherapy on the antioxidant-oxidant status in preterm neonates with jaundice. Indian Pediatr. 2017;54(8):644–6. Available from: https://doi.org/10.1007/s13312-017-1127-x
Nizam MA, Alvi AS, Hamdani MM, Lalani AS, Sibtain SA, Bhangar NA. Efficacy of double versus single phototherapy in treatment of neonatal jaundice: a meta-analysis. Eur J Pediatr. 2020;179(6):865-874. doi:10.1007/s00431-020-03583-x
Lee Wan Fei S, Chew KS, Pawi S, Chong LT, Abdullah KL, Lim LT, et al. Systematic Review of the Effect of Reflective Materials Around a Phototherapy Unit on Bilirubin Reduction Among Neonates With Physiologic Jaundice in Developing Countries. JOGNN - J Obstet Gynecol Neonatal Nurs [Internet]. 2018;47(6):795–802. Available from: https://doi.org/10.1016/j.jogn.2018.07.008
Tiribelli C. Blue or green for yellow? Which light is more beneficial for jaundiced newborns? Pediatr Res [Internet]. 2019;85(6):747. Available from: http://dx.doi.org/10.1038/s41390-019-0350-7
Kang S, Qin H, Zhang L, Huang Y, Bai X, Li X, et al. Efficient Photocatalytic Bilirubin Removal over the Biocompatible Core/Shell P25/g-C3 N4 Heterojunctions with Metal-free Exposed Surfaces under Moderate Green Light Irradiation. Sci Rep. 2017;7(December 2016):1–11. Available from: https://doi.org/10.1038/srep44338
Hospital SMNN at LPC. Frequently Asked Questions About Phototherapy [Internet]. 2006. [cited 2020 Feb 7]. Available from: https://med.stanford.edu/newborns/professional-education/jaundice-and-phototherapy/faqs-about-phototherapy.html#what-are-the-risks-of-phototherapy?
Wei CC, Lin CL, Shen TC, Kao CH. Neonatal jaundice and risks of childhood allergic diseases: A population-based cohort study. Pediatr Res. 2015;78(2):223–30. Available from: https://doi.org/10.1038/pr.2015.89
Bulut Ö, Dürüyen S. Impacts of phototherapy on DNA damage and total oxidant/ antioxidant status in jaundiced newborns. Turk J Pediatr. 2019;61(5):697–703. Available from: https://doi.org/10.24953/turkjped.2019.05.008
Khan M, Malik KA, Bai R. Hypocalcemia in jaundiced neonates receiving phototherapy. Pakistan J Med Sci. 2016;32(6):1449–52. Available from: https://doi.org/10.12669/pjms.326.10849
Mosayebi Z, Rahmani M, Ardakani SB, Sheikh M, Shariat M, Rezaeizadeh G. Evaluation of serum zinc levels in hyperbilirubinemic neonates before and after phototherapy. Iran J Pediatr. 2016;26(3):3–6. Available from: https://dx.doi.org/10.5812%2Fijp.4146
Newman TB, Wu YW, Kuzniewicz MW, Grimes BA, McCulloch CE. Childhood seizures after phototherapy. Pediatrics. 2018;142(4). Available from: https://doi.org/10.1542/peds.2018-0648
Auger N, Laverdière C, Ayoub A, Lo E, Luu TM. Neonatal phototherapy and future risk of childhood cancer. Int J Cancer. 2019;145(8):2061–9. Available from: https://doi.org/10.1002/ijc.32158
Shahriarpanah S, Tehrani FHE, Davati A, Ansari I. Effect of phototherapy on serum level of calcium, magnesium and vitamin D in infants with hyperbilirubinemia. Iran J Pathol. 2018;13(3):357–62. Available from: https://pubmed.ncbi.nlm.nih.gov/30636959/
Uhrikova Z, Zibolen M, Javorka K, Chladekova L, Javorka M. Hyperbilirubinemia and phototherapy in newborns: Effects on cardiac autonomic control. Early Hum Dev [Internet]. 2015;91(6):351–6. Available from: http://dx.doi.org/10.1016/j.earlhumdev.2015.03.009
Ng PL, Carlisle T, Ly M, Morris SA. Heating of newborn infants due to blue light-emitting diode fibreoptic phototherapy pads. Neonatology. 2017;112(2):103–9. Available from: https://doi.org/10.1159/000464318
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