O PAPEL DO TNF-α NO DESENVOLVIMENTO DE DOENÇAS PSIQUIÁTRICAS
UMA REVISÃO SISTEMÁTICA
Abstract
This paper aims to perform a systematic review of the literature on the role of tumor necrosis factor in the development of psychiatric disorders. A systematic review of the literature was carried out in SciELO, PubMed, Science Direct and MEDLINE. The Health Science Descriptors used for the search were: (TNF) (dependence) ("psychiatric disease or psychiatric disorders"). A total of 11 articles made up the final sample for this study. The studies pointed out that psychiatric disorders are associated with high concentrations of tumor necrosis factor, being modulated from exposure to inflammatory substances, such as the consumption of alcohol and other drugs. Therefore, the literature showed that high levels of TNF-α have a significant correlation with mental disorders, being triggered by the production of exogenous factors, such as alcohol consumption.
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ABRAHAM, Lawrence J.; KROEGER, Karen M. Impact of the‐308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease. Journal of leukocyte biology, v. 66, n. 4, p. 562-566, 1999.
BLOKHIN, Ilya O. et al. Molecular mechanisms of psychiatric diseases. Neurobiology of disease, v. 146, p. 105136, 2020.
CERRI, A. P. et al. -308(G/A) TNF-alpha gene polymorphism and risk of depression late in the life. Archives of Gerontology and Geriatrics, v. 49, p. 29–34, jan. 2009.
CHANG, He Benny et al. The role of substance use, smoking, and inflammation in risk for suicidal behavior. Journal of affective disorders, v. 243, p. 33-41, 2019.
GAŁECKI, Piotr; TALAROWSKA, Monika. Inflammatory theory of depression. Psychiatr Pol, v. 52, n. 3, p. 437-447, 2018.
GARCÍA-MARCHENA, Nuria et al. Inflammatory mediators and dual depression: Potential biomarkers in plasma of primary and substance-induced major depression in cocaine and alcohol use disorders. PLoS One, v. 14, n. 3, p. e0213791, 2019.
GIRARD, Murielle; MALAUZAT, Dominique; NUBUKPO, Philippe. Serum inflammatory molecules and markers of neuronal damage in alcohol-dependent subjects after withdrawal. The World Journal of Biological Psychiatry, v. 20, n. 1, p. 76-90, 2019.
KANG, H.-J. et al. Associations of cytokine genes with Alzheimer’s disease and depression in an elderly Korean population. Journal of neurology, neurosurgery, and psychiatry, v. 86, n. 9, p. 1002–7, set. 2015
KILIC, Faruk et al. Serum tumor necrosis factor-like weak inducer of apoptosis levels are elevated in schizophrenia. Brazilian Journal of Psychiatry, v. 43, p. 242-246, 2020.LEFF GELMAN, P. et al. The cytokine profile of women with severe anxiety and depression during pregnancy. Bmc Psychiatry, v. 19, n. 1, p. 1-11, 2019.
LIN, Chen et al. Relationship between TNF-α levels and psychiatric symptoms in first-episode drug-naïve patients with schizophrenia before and after risperidone treatment and in chronic patients. BMC psychiatry, v. 21, p. 1-9, 2021.
LÜLEYAP, H. U. et al. Association Between Obsessive Compulsive Disorder And Tumor Necrosis Factor-Α Gene–308 (G> A) And–850 (C> T) Polymorphisms In Turkish Children. Balkan Journal of Medical Genetics, v. 15, n. 2, p. 61-66, 2012.
MARTINEZ, Priscilla et al. Circulating cytokine levels are associated with symptoms of depression and anxiety among people with alcohol and drug use disorders. Journal of neuroimmunology, v. 318, p. 80-86, 2018.
QIDWAI, T.; KHAN, F. Tumour necrosis factor gene polymorphism and disease prevalence. Scandinavian journal of immunology, v. 74, n. 6, p. 522-547, 2011.
SHUKLA, Pradeep K. et al. Deletion of TLR-4 attenuates fetal alcohol exposure-induced gene expression and social interaction deficits. Alcohol, v. 73, p. 73-78, 2018.
SLAVICH, George M.; IRWIN, Michael R. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychological bulletin, v. 140, n. 3, p. 774, 2014.
SUCHANEK-RAIF, Renata et al. Polymorphic variants of TNFR2 gene in schizophrenia and its interaction with-308G/A TNF-α gene polymorphism. Mediators of Inflammation, v. 2018, 2018.
TOFT, Helge et al. The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment. BMC psychiatry, v. 18, n. 1, p. 1-10, 2018.
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