Association of interferon gamma (IFN-γ) with the development of psychiatric illnesses and addictive behavior in alcohol users: A systematic review

UMA REVISÃO SISTEMÁTICA

Authors

  • Pedro Bezerra de Oliveira Neto Federal University of Alagoas - Arapiraca Campus
  • Letícia Henrique Leite da Silva Federal University of Alagoas - Arapiraca Campus
  • Carla Souza dos Anjos Federal University of Alagoas - Arapiraca Campus
  • Bruna Brandão dos Santos Federal University of Alagoas - Arapiraca Campus
  • Jammily de Oliveira Vieira Moreira Federal University of Alagoas - Arapiraca Campus
  • Bárbara Rayssa Correia dos Santos Federal University of Alagoas - Arapiraca Campus
  • Elaine Virgínia Martins de Souza Figueiredo Federal University of Alagoas - Arapiraca Campus

Keywords:

Interferon gamma, Psychiatric disorder, Alcohol

Abstract

Abuse in alcohol consumption is associated with the development and complications of several psychiatric diseases. It is observed that some studies seek to understand the role of the immune system in neurological changes. Interferon gamma (IFN-γ), a pro-inflammatory cytokine, has immunomodulatory activity. The objective of this work is to carry out a systematic review of the literature on the role of IFN-γ in the development of psychiatric illnesses in alcohol users. For review, the following databases were used: Pubmed, ScienceDirect and BVS, with the keywords, “Interferon gamma”, “Psychiatric disease”, “Psychiatric disorders”, and “Alcohol” modulated by the AND operator, after applying the criteria of inclusion and exclusion. Psychiatric disorders such as: schizophrenia, bipolar mania and panic disorder were associated with low levels of IFN-γ, depression was associated with elevated levels, stable secretion levels were found in schizophrenic patients, studies involving IFN-γ and psychiatric illnesses in alcohol users were not found, which is a promising field for the development of research.

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Author Biographies

Pedro Bezerra de Oliveira Neto, Federal University of Alagoas - Arapiraca Campus

Graduating in Biological Sciences from the Federal University of Alagoas (UFAL) Campus Arapiraca. Scholarship holder in the Scientific Initiation Program (PIBIC) in the area of human genetics at the Molecular Biology and Gene Expression Laboratory (LABMEG) at the Federal University of Alagoas

Letícia Henrique Leite da Silva, Federal University of Alagoas - Arapiraca Campus

Graduating in Biological Sciences from the Federal University of Alagoas - Campus Arapiraca. Member of the Arapiraquense League of Human Anatomy at UFAL and member of the Laboratory of Molecular Biology and Gene Expression as a student of the Institutional Program for Scientific Initiation Scholarships, currently in the project: Development of psychiatric comorbidities in alcohol users and association with polymorphisms in cytokine genes and oxidative stress, of a population from Alagoas

Carla Souza dos Anjos, Federal University of Alagoas - Arapiraca Campus

Student in Nursing at the Federal University of Alagoas. She received a scholarship from Proex, UFAL as a member of the project: "Health interventions in users of psychoactive substances with an emphasis on mental health: promoting community circles" at the Federal University of Alagoas, Arapiraca campus. She served as a member of the Academic League of Collective Health at the CESMAC / Maceió faculty. She also acted as secretary of the board of the Academic League of Collective Health of Faculdade CESMAC / Maceió. She acted as a volunteer researcher in the scientific initiation project: "PRENATAL EXPOSURE TO LICIT DRUGS AND ITS CORRELATION WITH GENETIC BIOMARKERS AND MONITORING IN MATERNAL AND NEONATAL HEALTH: multiphase study of mixed methods" (PIBIC/CNPQ/UFAL). She was a member of the Academic League of Nursing in Integral Health of the Neonate and Child (LAESINC) of the Federal University of Rio de Janeiro. She is a member of the Education Program for Work for Health-PET Health: Management and Assistance. She was a member of the extension project: "Integration teaching-service to strengthen the IMCI Child Strategy in the municipality of Arapiraca-AL". She acts as a volunteer researcher in the scientific initiation project "Development of psychiatric comorbidities in alcohol users and association with polymorphisms in cytokine genes and oxidative stress, in a population from Alagoas". She is a member of the Academic League of Child Health Nursing (LAESC / UFAL), at the Federal University of Alagoas, where she holds the position of Scientific Director. It is part of the research project "Usability analysis of the IMCI mobile application by health professionals in Primary Care" at the Federal University of Fluminense (UFF)

Bruna Brandão dos Santos, Federal University of Alagoas - Arapiraca Campus

Nurse graduated from the Federal University of Alagoas (UFAL) / Arapiraca Campus. Member of the Laboratory of Molecular Biology and Genetics - LABMG. Member of the Biomarkers and Health Monitoring Research Group (BMS), at the Federal University of Alagoas. Master's student in Health Sciences - PPGCS-UFAL, Postgraduate in Public Health with an emphasis on family health. She has experience in health management with the coordination of the Tuberculosis and Leprosy Program in 2021. She currently teaches technical courses in nursing and performs advanced home treatment of wounds and dressings, with laser therapy

Jammily de Oliveira Vieira Moreira, Federal University of Alagoas - Arapiraca Campus

Master in Nutrition from the Federal University of Alagoas, following a line of research: Experimental and Clinical Bases of Nutrition. She has a postgraduate degree in Clinical-Institutional Psychopedagogy ESAB (2013) and a degree in Biological Sciences (Licenciatura and Bachelor's Degree) from the Federal University of Alagoas (2008). She served as a high school teacher at Colégio Adventista Dr. Milton Afonso - Alagoas. She is currently a Technician in Educational Affairs at the Institute of Humanities, Arts and Sciences (IHAC) at UFBA. With experience mainly in the following subjects: Education and Bulling, Education and Low Cost Experiments, Food Safety, Food Biotechnology and Microbiology.

Bárbara Rayssa Correia dos Santos, Federal University of Alagoas - Arapiraca Campus

  Degree in Biological Sciences from the Federal University of Alagoas - Ufal (Arapiraca campus). Master in Health Sciences (concentration area: Epidemiology and Etiopathogenesis of Human Diseases) by the Institute of Biological and Health Sciences (ICBS) of the Federal University of Alagoas (Campus A. C. Simões). Member of the Laboratory of Molecular Biology and Gene Expression (Campus Arapiraca). Member of the Research Group Biomarkers and Health Monitoring (BMS)

Elaine Virgínia Martins de Souza Figueiredo, Federal University of Alagoas - Arapiraca Campus

PhD in Biotechnology by the Northeast Biotechnology Network (RENORBIO) - UFPE. Master in Biochemistry and Physiology (UFPE). Degree in Biomedicine and Pharmacy (UFPE). Professor at the Federal University of Alagoas (UFAL) - Campus Arapiraca teaching the disciplines: Pharmacology and Biochemistry. She is currently coordinator of the Laboratory of Molecular Biology and Gene Expression (LABMEG). Professor of the permanent staff of the Graduate Program in Health Sciences (concentration area: Epidemiology and Etiopathogenesis of Human Diseases) at the Institute of Biological and Health Sciences (ICBS) of the Federal University of Alagoas (Campus A. C. Simões). She coordinates the CNPQ Research Group entitled Biomarkers and Health Monitoring (BMS). Currently develops research focusing on: medication adherence, identification of immunological and genetic biomarkers in infectious diseases (Coronavirus, Dengue, Mayaro, Zika virus, Chikungunya, HPV), psychiatric disorders and use of psychoactive substances

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Published

2023-08-09

How to Cite

Bezerra de Oliveira Neto, P., Henrique Leite da Silva, L., Souza dos Anjos, C., Brandão dos Santos, B., de Oliveira Vieira Moreira, J., Rayssa Correia dos Santos, B. ., & Virgínia Martins de Souza Figueiredo, E. . (2023). Association of interferon gamma (IFN-γ) with the development of psychiatric illnesses and addictive behavior in alcohol users: A systematic review: UMA REVISÃO SISTEMÁTICA. REVISTA ELETRÔNICA EXTENSÃO EM DEBATE, 12(14). Retrieved from https://seer.ufal.br/index.php/extensaoemdebate/article/view/15356

Issue

Vol. 12 No. 14 (2023): Edição Especial - Anais de Enfermagem/2023

Section

RESUMO EXPANDIDO

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Copyright (c) 2023 REVISTA ELETRÔNICA EXTENSÃO EM DEBATE

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